drug repurposing

/Tag:drug repurposing

“Party Drug” Repurposed for Resistant Major Depression

The anesthetic drug ketamine has a reputation as an illicit party drug due to its hallucinogenic effects. However, research now shows that ketamine has rapid antidepressant effects and could be effective for those who aren’t helped by standard treatments for major depression. In an optimized study design, intravenous ketamine improved depression severity in 64% of treatment-resistant patients 24 […]

MS drug investigated for uses in other neurological diseases

The drug fingolimod restores hippocampal synaptic plasticity and improves memory function, and as such, it is commonly used to treat patients with multiple sclerosis. Researchers at the University of Barcelona and the August Pi Sunyer Biomedical Research Institute investigated other applications of the drug; preclinical results show an improvement of cognitive deficits in mice with […]

Two anti-malaria drugs could be potential treatment for Parkinson’s disease

Parkinson’s disease currently affects about 10 million people worldwide, with no cure or treatment. Thanks to an international team of scientists, including Professor Kwang-Soo Kim in the US and Associate Professor Yoon Ho Sup in Singapore, this may change. The team identified two anti-malaria drugs, Chloroquine and Armodiaquine as a potential treatment. The drugs activate Nurr1, a class of […]

Repurposed Drug Treats Old Biothreat

Although no longer a threat to the majority of the world, the Centers for Disease Control and Prevention the plague is still classified as a Category A biothreat pathogen, with mortality rates ranging from 50-100 percent if untreated. Up until now, there has only been one treatment for the pneumonic and septicemic plague; a problem since […]

Machine-learning technique utilized for drug repurposing

Insilico Medicine, Inc. is utilizing a machine learning technique called deep learning for drug repurposing research. This new process will be part of their DeepPharma (TM) platform. The technique borrows some of its principles from the brain and gives computers the ability to recognize speech and categorize images–given these advances, it will be able to greatly accelerate research. Next […]

Potential anticancer agent found through Phentolamine repurposing

The scientific journal The Prostate just published research on a new potential anticancer agent found through repurposing of phentolamine. Phentolamine is an alpha blocker; when given by injection, it causes blood vessels to expand, thereby increasing blood flow. It is used commercially to treat hypertension and erectile dysfunction under the names OraVerse and Regitine in the United States. […]

Researchers Finding New Uses for Old Vaccines

Dr. Denise Faustmann, the director of immunobiology at Mass General and associate professor of medicine at Harvard Medical School, is repurposing the common tuberculosis vaccine BCG. Faustmann is currently working on treating Type 1 diabetes with the vaccine, and has two upcoming clinical trials possible with help from Cures Within Reach. Additionally, this treatment may also be useful for other autoimmune […]

Drugs to treat Ebola may have been on pharmacy shelves all along

Though the 2014 ebola outbreak has been relatively contained, there is still no vaccine or treatment specifically built for the disease. Since the drug development process can take over a decade, medical personnel faced with emergency outbreaks often face this problem. However, repurposing research at the US Army Medical Research Institute of Infectious Diseases has […]

How aspirin fights colorectal cancer

Aspirin, which is commonly repurposed for several different uses, has been shown to reduce the risk of colorectal cancer. However, a new study at the University of Minnesota has elucidated just how the drug is able to do so. A tissue growth factor known as EGFR is often overexpressed in patients with colorectal cancer, and aspirin […]

Repurposed anti-cholesterol drug could improve treatment-resistant anemias

For years, physicians and researchers have been searching for a treatment that helps patients suffering from Diamond Blackfan Anemia (DBA), a bone marrow failure syndrome that affects only 25-35 children per year in America. Since it is resistant to treatments commonly used for anemia, many must rely on glucocorticoid treatments with harsh side effects, with many […]