cancer

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Drug Repurposing Yields Hope for Reversing Effects of Parkinson’s

Preliminary findings from a small-scale study done by Georgetown University Medical Center researches indicate that a medication approved to treat leukemia may halt or reverse the progression of Parkinson’s disease and Lewy body dementia.

Dr. Moussa states that their work “has been focused on repositioning this already-FDA-approved drug, that we now have a good safety profile to […]

Randy Forbes: Trailblazing a cure

Randy Forbes introduces us to Dr.  Emil Freireich, who in 1995 took on the challenge of Children’s Leukemia. Dr. Freireich wondered if combining several chemotherapy treatments simultaneously would increase the success rate of remissions.

Over the course of several trials, Dr. Freireich, along with a colleague, discovered a multi-drug treatment for leukemia. Their discovery led to cures that […]

International CTCA study shows statins could be effective against small cell lung cancer

Small cell lung cancer is one of the most aggressive types of cancer, and in a recent study statins, a class of drugs primarily used to lower cholesterol in patients at risk for heart disease, appeared to provide an increase in overall survival for those cancer patients who received them.

This study specifically examined late-stage SCLC patients who […]

One-cent wonder drug?

“Drug repurposing can potentially see a cheap, good, and powerful drug like aspirin prevent and even treat cancer effectively,” said Dr Toh Han Chong, deputy director of National Cancer Centre, Singapore. He and Dr. Chia are leading the first global clinical trial, named Ascolt, to see if aspirin can stop the recurrence of cancer after […]

Arthritis Drug Successful in Blood Cancer Treatment

The rheumatoid arthritis drug methotrexate, has been show to be a cheaper and effective alternative for blood cancer sufferers. Researchers have found that methotrexate can have the same effect on patients with blood disorders that the drug Ruxolitinib has. Because methotrexate is a World Health Organization ‘Essential Medicine,’ this also means that this well understood drug could […]

Could a Cancer Drug Reverse Parkinson’s Disease?

A leukemia drug know as Nilotinib that is already on the market might also be able to treat the hallmark signs of Parkinson’s disease. This break through study represents the first time a therapy appears to reverse cognitive and motor decline in patients with Parkinson’s disease, according to the researchers.

Specifically, this trial builds on animal studies […]

Machine-learning technique utilized for drug repurposing

Insilico Medicine, Inc. is utilizing a machine learning technique called deep learning for drug repurposing research. This new process will be part of their DeepPharma (TM) platform. The technique borrows some of its principles from the brain and gives computers the ability to recognize speech and categorize images–given these advances, it will be able to greatly accelerate research. Next […]

Potential anticancer agent found through Phentolamine repurposing

The scientific journal The Prostate just published research on a new potential anticancer agent found through repurposing of phentolamine. Phentolamine is an alpha blocker; when given by injection, it causes blood vessels to expand, thereby increasing blood flow. It is used commercially to treat hypertension and erectile dysfunction under the names OraVerse and Regitine in the United States. […]

Repurposed experimental cancer drug restores brain function in mouse models of Alzheimer’s disease

Currently undergoing clinical trials, the drug saracatinib, which was originally developed for cancer, is being repurposed as a treatment for Alzheimer’s. Animal testing at the Yale University School of Medicine showed a decrease in memory loss and reversal of brain damage caused by the mouse model of the disease. After obtaining the drug from AstraZeneca, researchers were able […]

Saccharin could sweeten the deal for cancer-fighting drugs

In an exciting new discovery that could bring about significant progress in cancer research, it appears that saccharin, an artificial sweetener, can bind selectively to a protein involved in many aggressive forms of cancer. Since the protein is similar to many others that are abundant in the body, finding a way to target this specific […]