Chemotherapy

/Chemotherapy

ATRA & Leukemia

Another cancer treatment success story involves the repurposing of all-trans retinoic acid (ATRA), a chemical compound historically used in medications that treat severe acne. Though it does not have anti-cancer properties when used alone, ATRA has been combined with traditional chemotherapy and to induce complete remission in 90% of patients with acute promyelocytic leukemia. The drug combination has […]

Methrotrexate & Rheumatoid Arthritis

Dose adjustments to existing treatments
The effects of certain drugs can vary greatly based on dosage, making them ideal candidates for repurposing research. Methrotrexate was developed as a chemotherapy drug in the 1950s and has since been administered at a very high dose to cancer patients. At a low dose, and because of totally different mechanisms of the drug, […]