Drugs

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“Rescued” drug could be safer treatment for Bipolar Disorder

The drug Ebselen was originally developed for strokes,but destined for the scrap heap.  It has been rescued by Oxford scientists, who may have found it a new role in treating bipolar disorder.

A team from Oxford University used a database of ‘failed’ drugs, found to be safe but ineffective for their proposed use, to identify Ebselen as a […]

One-cent wonder drug?

“Drug repurposing can potentially see a cheap, good, and powerful drug like aspirin prevent and even treat cancer effectively,” said Dr Toh Han Chong, deputy director of National Cancer Centre, Singapore. He and Dr. Chia are leading the first global clinical trial, named Ascolt, to see if aspirin can stop the recurrence of cancer after […]

Arthritis Drug Successful in Blood Cancer Treatment

The rheumatoid arthritis drug methotrexate, has been show to be a cheaper and effective alternative for blood cancer sufferers. Researchers have found that methotrexate can have the same effect on patients with blood disorders that the drug Ruxolitinib has. Because methotrexate is a World Health Organization ‘Essential Medicine,’ this also means that this well understood drug could […]

Could a Cancer Drug Reverse Parkinson’s Disease?

A leukemia drug know as Nilotinib that is already on the market might also be able to treat the hallmark signs of Parkinson’s disease. This break through study represents the first time a therapy appears to reverse cognitive and motor decline in patients with Parkinson’s disease, according to the researchers.

Specifically, this trial builds on animal studies […]

Nobel Prize Winning Drug Ivermectin May Fight Malaria

Resurrecting old drugs for unmet medical needs—known more formally as drug repurposing—was an important message in the Nobel Prize for Medicine earlier this month. It came up today, too, with the intriguing study showing that the antiparasitic drug, ivermectin, appears promising for disrupting malaria transmission.

William Campbell, 85, and biochemist Satoshi Omura of Japan share half […]

“Party Drug” Repurposed for Resistant Major Depression

The anesthetic drug ketamine has a reputation as an illicit party drug due to its hallucinogenic effects. However, research now shows that ketamine has rapid antidepressant effects and could be effective for those who aren’t helped by standard treatments for major depression. In an optimized study design, intravenous ketamine improved depression severity in 64% of treatment-resistant patients 24 […]

MS drug investigated for uses in other neurological diseases

The drug fingolimod restores hippocampal synaptic plasticity and improves memory function, and as such, it is commonly used to treat patients with multiple sclerosis. Researchers at the University of Barcelona and the August Pi Sunyer Biomedical Research Institute investigated other applications of the drug; preclinical results show an improvement of cognitive deficits in mice with […]

Two anti-malaria drugs could be potential treatment for Parkinson’s disease

Parkinson’s disease currently affects about 10 million people worldwide, with no cure or treatment. Thanks to an international team of scientists, including Professor Kwang-Soo Kim in the US and Associate Professor Yoon Ho Sup in Singapore, this may change. The team identified two anti-malaria drugs, Chloroquine and Armodiaquine as a potential treatment. The drugs activate Nurr1, a class of […]

New technology repurposed for anti-aging drugs

Gerontology, or the study of aging, is a field that greatly benefits from device repurposing research. Scientists often struggle to complete drug tests on live subjects, leading to long and costly products. However, Insilico Medicine, based at the Emerging Technology Centers at the Johns Hopkins University, has come up with a big data based software called the […]

Neuro Vigor repurposing blood pressure drug for multiple sclerosis

Neuro Vigor is an Indiana startup from Purdue University, built on 15 years of research from neuroscientist Riyi Shi. They have found a new use for the generic drug hydralazine, which is commonly used in cases of hyptertension. Shi is working with the drug as treatment for neurodegenerative diseases such as neuropathies, Parkinson’s, and multiple sclerosis. Hydralazine can bind to […]