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So far has created 19 blog entries.

Nobel Prize Winning Drug Ivermectin May Fight Malaria

Resurrecting old drugs for unmet medical needs—known more formally as drug repurposing—was an important message in the Nobel Prize for Medicine earlier this month. It came up today, too, with the intriguing study showing that the antiparasitic drug, ivermectin, appears promising for disrupting malaria transmission.

William Campbell, 85, and biochemist Satoshi Omura of Japan share half […]

“Party Drug” Repurposed for Resistant Major Depression

The anesthetic drug ketamine has a reputation as an illicit party drug due to its hallucinogenic effects. However, research now shows that ketamine has rapid antidepressant effects and could be effective for those who aren’t helped by standard treatments for major depression. In an optimized study design, intravenous ketamine improved depression severity in 64% of treatment-resistant patients 24 […]

MS drug investigated for uses in other neurological diseases

The drug fingolimod restores hippocampal synaptic plasticity and improves memory function, and as such, it is commonly used to treat patients with multiple sclerosis. Researchers at the University of Barcelona and the August Pi Sunyer Biomedical Research Institute investigated other applications of the drug; preclinical results show an improvement of cognitive deficits in mice with […]

Two anti-malaria drugs could be potential treatment for Parkinson’s disease

Parkinson’s disease currently affects about 10 million people worldwide, with no cure or treatment. Thanks to an international team of scientists, including Professor Kwang-Soo Kim in the US and Associate Professor Yoon Ho Sup in Singapore, this may change. The team identified two anti-malaria drugs, Chloroquine and Armodiaquine as a potential treatment. The drugs activate Nurr1, a class of […]

New technology repurposed for anti-aging drugs

Gerontology, or the study of aging, is a field that greatly benefits from device repurposing research. Scientists often struggle to complete drug tests on live subjects, leading to long and costly products. However, Insilico Medicine, based at the Emerging Technology Centers at the Johns Hopkins University, has come up with a big data based software called the […]

Neuro Vigor repurposing blood pressure drug for multiple sclerosis

Neuro Vigor is an Indiana startup from Purdue University, built on 15 years of research from neuroscientist Riyi Shi. They have found a new use for the generic drug hydralazine, which is commonly used in cases of hyptertension. Shi is working with the drug as treatment for neurodegenerative diseases such as neuropathies, Parkinson’s, and multiple sclerosis. Hydralazine can bind to […]

Clinical Molecule Ebselen Repurposed to Combat Drug Resistant Pathogens

A huge problem in treating and preventing infection are newly-emerged multidrug-resistant pathogens. These pathogens are affecting an increasing range of infections caused by bacteria, parasites, viruses and fungi. As such, research finding novel antimicrobials and novel approaches to develop them is a pressing need, making it a perfect field for repurposing. The organoselenium clinical molecule Ebselen has been […]

Repurposed Drug Treats Old Biothreat

Although no longer a threat to the majority of the world, the Centers for Disease Control and Prevention the plague is still classified as a Category A biothreat pathogen, with mortality rates ranging from 50-100 percent if untreated. Up until now, there has only been one treatment for the pneumonic and septicemic plague; a problem since […]

Machine-learning technique utilized for drug repurposing

Insilico Medicine, Inc. is utilizing a machine learning technique called deep learning for drug repurposing research. This new process will be part of their DeepPharma (TM) platform. The technique borrows some of its principles from the brain and gives computers the ability to recognize speech and categorize images–given these advances, it will be able to greatly accelerate research. Next […]

Potential anticancer agent found through Phentolamine repurposing

The scientific journal The Prostate just published research on a new potential anticancer agent found through repurposing of phentolamine. Phentolamine is an alpha blocker; when given by injection, it causes blood vessels to expand, thereby increasing blood flow. It is used commercially to treat hypertension and erectile dysfunction under the names OraVerse and Regitine in the United States. […]